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Addiction is a brain disease that destroys lives, devastates families and tears at the very fabric of society. Effective prevention and treatment of addiction requires a clear understanding of the complex brain mechanisms that underlie addictive behaviors, and research has provided a fascinating view of how substance abuse hijacks neuronal circuits involved in reward and motivation and causes profound and persistent changes in behavior. Now, a special issue of the journal Neuron, published on February 24th by Cell Press, provides new insight into to the most recent advances in addiction research and highlights the complexities associated with the neurobiological and societal impacts of addiction, as well as strategies for the prevention and treatment of substance abuse. More…..

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